Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC057
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-09-27 11:03
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment new patien madopar 250mg 3x1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 36 individuals with a value less than 0.69 were subsequently diagnosed with PD. That is, 85.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.69 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 14, 'TN': 12, 'TP': 28, 'FP': 18}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 18, 'TN': 14, 'TP': 24, 'FP': 16}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 30, 'TN': 25, 'TP': 12, 'FP': 5}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 12, 'TP': 22, 'FP': 18}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 17.156
timePerCircleCoV 0.125005
timePerCircleSlope -0.0252231
meanError 1.4668
tremorFreq 6.64062
tremorRelPower 36.6497
tremorGyroAmpMean 0.0175635
tremorGyroAmpSlope -0.00170646
tremorGyroAmpCoV 0.643497
tremorCoordAmpMean 0.0340462
tremorCoordAmpSlope 0.00152735
tremorCoordAmpCoV 0.410169
tremorAccAmpMean 0.027706
tremorAccAmpSlope 0.000942646
tremorAccAmpCoV 0.382185
tremorPcRelVar 0.610371
tremorPcX -0.245114
tremorPcY -0.969494

Circle Segment 1

Duration 18.6 s, Accuracy Estimate 1.209 (lower is better)

Circle Segment 2

Duration 17.56 s, Accuracy Estimate 1.624 (lower is better)

Circle Segment 3

Duration 16.64 s, Accuracy Estimate 1.069 (lower is better)

Circle Segment 4

Duration 17.84 s, Accuracy Estimate 1.312 (lower is better)

Circle Segment 5

Duration 20.48 s, Accuracy Estimate 1.401 (lower is better)

Circle Segment 6

Duration 17.92 s, Accuracy Estimate 1.27 (lower is better)

Circle Segment 7

Duration 17.52 s, Accuracy Estimate 1.434 (lower is better)

Circle Segment 8

Duration 16.8 s, Accuracy Estimate 1.351 (lower is better)

Circle Segment 9

Duration 16.08 s, Accuracy Estimate 1.418 (lower is better)

Circle Segment 10

Duration 12.12 s, Accuracy Estimate 2.58 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 28.54
timePerSpiralCoV 0.192371
timePerSpiralSlope -0.0573783
meanError 2.92203
tremorFreq 6.73828
tremorRelPower 69.8545
tremorGyroAmpMean 0.0434794
tremorGyroAmpSlope 0.00793127
tremorGyroAmpCoV 0.766709
tremorCoordAmpMean 0.0762355
tremorCoordAmpSlope 0.0068082
tremorCoordAmpCoV 0.551798
tremorAccAmpMean 0.0650324
tremorAccAmpSlope 0.00720676
tremorAccAmpCoV 0.598082
tremorPcRelVar 0.840577
tremorPcX -0.577276
tremorPcY 0.816549

Spiral Segment 1

Duration 38.32 s, Accuracy Estimate 2.486 (lower is better)

Spiral Segment 2

Duration 34.2 s, Accuracy Estimate 2.843 (lower is better)

Spiral Segment 3

Duration 33.88 s, Accuracy Estimate 2.639 (lower is better)

Spiral Segment 4

Duration 32.12 s, Accuracy Estimate 2.53 (lower is better)

Spiral Segment 5

Duration 25.68 s, Accuracy Estimate 2.898 (lower is better)

Spiral Segment 6

Duration 24.36 s, Accuracy Estimate 2.83 (lower is better)

Spiral Segment 7

Duration 24.72 s, Accuracy Estimate 2.852 (lower is better)

Spiral Segment 8

Duration 23.16 s, Accuracy Estimate 2.845 (lower is better)

Spiral Segment 9

Duration 24.72 s, Accuracy Estimate 4.253 (lower is better)

Spiral Segment 10

Duration 24.24 s, Accuracy Estimate 3.044 (lower is better)

Elel

eDurationMean 0.412432
eDurationStd 0.106443
eDurationStdnorm 0.258085
eDurationMedian 0.39
eDurationQuartdelta 0.1
eDurationQuartdeltanorm 0.25641
eDurationKurt 7.79808
eDurationTrenddiff -0.0025
eDurationTrendratio 0.993631
eWidthMean 10.7545
eWidthStd 3.74231
eWidthStdnorm 0.347976
eWidthMedian 9.477
eWidthQuartdelta 5.52825
eWidthQuartdeltanorm 0.583333
eWidthKurt 4.15128
eWidthTrenddiff -0.4095
eWidthTrendratio 0.958333
eHeightMean 16.1871
eHeightStd 2.86739
eHeightStdnorm 0.17714
eHeightMedian 15.795
eHeightQuartdelta 3.18825
eHeightQuartdeltanorm 0.201852
eHeightKurt 2.57346
eHeightTrenddiff -0.936
eHeightTrendratio 0.944056
eAspectMean 0.65753
eAspectStd 0.151952
eAspectStdnorm 0.231095
eAspectMedian 0.647619
eAspectQuartdelta 0.19554
eAspectQuartdeltanorm 0.301937
eAspectKurt 2.62313
eAspectTrenddiff -0.0894633
eAspectTrendratio 0.867106
eSlantMean 0.474287
eSlantStd 0.138507
eSlantStdnorm 0.292032
eSlantMedian 0.480315
eSlantQuartdelta 0.158051
eSlantQuartdeltanorm 0.329057
eSlantKurt 3.57281
eSlantTrenddiff -0.0570106
eRtopMean 0.930826
eRtopStd 0.0435286
eRtopStdnorm 0.0467635
eRtopMedian 0.937063
eRtopQuartdelta 0.0505444
eRtopQuartdeltanorm 0.0539391
eRtopKurt 3.1971
eRtopTrenddiff -0.0204441
eRbotMean 0.214525
eRbotStd 0.108304
eRbotStdnorm 0.504854
eRbotMedian 0.223404
eRbotQuartdelta 0.137804
eRbotQuartdeltanorm 0.616836
eRbotKurt 3.32792
eRbotTrenddiff 0.0722244
eRrightMean 0.952369
eRrightStd 0.0392441
eRrightStdnorm 0.0412069
eRrightMedian 0.964706
eRrightQuartdelta 0.0473463
eRrightQuartdeltanorm 0.0490785
eRrightKurt 4.47934
eRrightTrenddiff -0.00371852
eRleftMean 0.125603
eRleftStd 0.053913
eRleftStdnorm 0.429234
eRleftMedian 0.125
eRleftQuartdelta 0.0688328
eRleftQuartdeltanorm 0.550663
eRleftKurt 2.83249
eRleftTrenddiff 0.0301473
lDurationMean 0.459079
lDurationStd 0.0664938
lDurationStdnorm 0.144842
lDurationMedian 0.45
lDurationQuartdelta 0.065
lDurationQuartdeltanorm 0.144444
lDurationKurt 6.58486
lDurationTrenddiff -0.03
lDurationTrendratio 0.93617
lWidthMean 16.0044
lWidthStd 3.88609
lWidthStdnorm 0.242814
lWidthMedian 16.38
lWidthQuartdelta 4.797
lWidthQuartdeltanorm 0.292857
lWidthKurt 3.52417
lWidthTrenddiff -1.053
lWidthTrendratio 0.935714
lHeightMean 28.7666
lHeightStd 5.15842
lHeightStdnorm 0.17932
lHeightMedian 30.069
lHeightQuartdelta 8.658
lHeightQuartdeltanorm 0.287938
lHeightKurt 2.65166
lHeightTrenddiff 8.19
lHeightTrendratio 1.33019
lAspectMean 0.564353
lAspectStd 0.131074
lAspectStdnorm 0.232255
lAspectMedian 0.532483
lAspectQuartdelta 0.163263
lAspectQuartdeltanorm 0.306607
lAspectKurt 2.32483
lAspectTrenddiff -0.161653
lAspectTrendratio 0.751472
lSlantMean 0.421118
lSlantStd 0.122453
lSlantStdnorm 0.29078
lSlantMedian 0.410375
lSlantQuartdelta 0.171922
lSlantQuartdeltanorm 0.418938
lSlantKurt 2.73976
lSlantTrenddiff -0.167341
lRtopMean 0.936859
lRtopStd 0.0395437
lRtopStdnorm 0.0422088
lRtopMedian 0.94727
lRtopQuartdelta 0.0588506
lRtopQuartdeltanorm 0.0621265
lRtopKurt 2.81579
lRtopTrenddiff -0.00863095
lRbotMean 0.197157
lRbotStd 0.085246
lRbotStdnorm 0.432377
lRbotMedian 0.187794
lRbotQuartdelta 0.141816
lRbotQuartdeltanorm 0.755167
lRbotKurt 2.83765
lRbotTrenddiff 0.0881738
lRrightMean 0.953179
lRrightStd 0.0353391
lRrightStdnorm 0.0370751
lRrightMedian 0.964176
lRrightQuartdelta 0.0367944
lRrightQuartdeltanorm 0.0381615
lRrightKurt 2.78025
lRrightTrenddiff -0.0104305
lRleftMean 0.121803
lRleftStd 0.0367986
lRleftStdnorm 0.302116
lRleftMedian 0.119258
lRleftQuartdelta 0.0459559
lRleftQuartdeltanorm 0.385347
lRleftKurt 2.47408
lRleftTrenddiff 0.00506586

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

FITTS Short Modified

meanTouchScore 0.660478
sumTouchScores 11.2281
meanMovementTime 0.940625
numTouches 17
undershootPercentage 11.7647
overshootPercentage 17.6471

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.604515
sumTouchScores 4.23161
meanMovementTime 2.1325
numTouches 7
undershootPercentage 14.2857
overshootPercentage 0

ZigZag

numZigzags 6
timePerZigzagMean 20.34
timePerZigzagCoV 0.177091
timePerZigzagSlope 0.0251159
meanError 2.42548
tremorFreq 7.51953
tremorRelPower 28.7691
tremorGyroAmpMean 0.0202032
tremorGyroAmpSlope -0.00218518
tremorGyroAmpCoV 0.36861
tremorCoordAmpMean 0.0674172
tremorCoordAmpSlope -0.00229669
tremorCoordAmpCoV 0.90454
tremorAccAmpMean 0.0357442
tremorAccAmpSlope -0.00236974
tremorAccAmpCoV 0.336372
tremorPcRelVar 0.7916
tremorPcX 0.0311526
tremorPcY -0.999515

ZigZag Segment 1

Duration 16.84 s, Accuracy Estimate 3.089 (lower is better)

ZigZag Segment 2

Duration 18.64 s, Accuracy Estimate 2.377 (lower is better)

ZigZag Segment 3

Duration 22.16 s, Accuracy Estimate 2.372 (lower is better)

ZigZag Segment 4

Duration 22.84 s, Accuracy Estimate 2.046 (lower is better)

ZigZag Segment 5

Duration 25.24 s, Accuracy Estimate 2.177 (lower is better)

ZigZag Segment 6

Duration 16.32 s, Accuracy Estimate 2.493 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 24.848
timePerZigzagCoV 0.333328
timePerZigzagSlope -0.18915
zigzagHeightMean 52.5022
zigzagHeightCoV 0.0233243
zigzagHeightSlope 0.000325153
meanError 0.0419869
tremorFreq 6.44531
tremorRelPower 24.0443
tremorGyroAmpMean 0.0228902
tremorGyroAmpSlope 0.0018032
tremorGyroAmpCoV 0.362569
tremorCoordAmpMean 0.0912508
tremorCoordAmpSlope 0.0030948
tremorCoordAmpCoV 1.18616
tremorAccAmpMean 0.039312
tremorAccAmpSlope 0.00140771
tremorAccAmpCoV 0.280525
tremorPcRelVar 0.86515
tremorPcX 0.163333
tremorPcY 0.986571

ZigZag Offset Segment 1

Duration 38.84 s, Accuracy Estimate 0.053 (lower is better)

ZigZag Offset Segment 2

Duration 25.24 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 3

Duration 21.88 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 4

Duration 20.64 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 5

Duration 17.64 s, Accuracy Estimate 0.055 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.9}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.69}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.33368210475344506}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8989351195497812}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5451176313235797}